Active • Host: HEK293 cells • AA: 19-786 • Tag: C-terminal His • MW: 84.8 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cadherin-16 Extracellular Domain (human, recombinant)

Item No. 44200

Product Insert (PDF)
Technical Information
Synonyms
  • CDH16
  • Kidney-specific Cadherin
  • Ksp-Cadherin
Purity
≥85% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/μg, determined by the LAL endotoxin assay
Source
Active recombinant C-terminal His-tagged human CDH16 extracellular domain expressed in HEK293 cells
Amino Acids
19-768
MW
84.8 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris with 100 mM sodium chloride and calcium chloride, pH 8.0
UniProt Accession №
O75309
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µg

    $318

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Cadherin-16 (CDH16) is a cell adhesion molecule with roles in embryonic development and cell growth.1,2 It is composed of seven extracellular cadherin repeats, a transmembrane domain, and a short cytoplasmic domain.2 CDH16 is expressed primarily in renal and thyroid tissues and localized to the plasma membrane. It promotes the formation of renal tubuli and the development of thyroid follicles during development, and its expression persists at high levels in the adult kidney and follicular cells of the adult thyroid gland.3 Reduced kidney and thyroid levels of CDH16 are associated with the development of cancer in those tissues. Urinary levels of CDH16 are decreased in patients with sepsis-induced acute kidney injury.4 Cayman’s Cadherin-16 Extracellular Domain (human, recombinant) protein can be used in binding assay and Western blot (WB) applications. This protein consists of 779 amino acids, has a calculated molecular weight of 84.8 kDa, and a predicted N-terminus of Lys19 after signal peptide cleavage.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lennartz, M., Csomós, H., Bernreuther, C., et al. Reduced CDH16 expression is linked to poor prognosis in clear cell renal cell carcinoma 16. Urol. Oncol. 40(7), 348.e341-348.e348 (2022).

    2. Wendeler, M.W., Jung, R., Himmelbauer, H., et al. Unique gene structure and paralogy define the 7D-cadherin family. Cell. Mol. Life Sci. 63(13), 1564-1573 (2006).

    3. Lennartz, M., Csomós, H., Chirico, V., et al. Cadherin-16 (CDH16) immunohistochemistry: A useful diagnostic tool for renal cell carcinoma and papillary carcinomas of the thyroid. Sci. Rep. 13(1), 12917 (2023).

    4. Li, Y., Long, J., Chen, J., et al. Analysis of spatiotemporal urine protein dynamics to identify new biomarkers for sepsis-induced acute kidney injury. Front. Physiol. 11, 139 (2020).