An antifilarial agent
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Diethylcarbamazine (citrate)

Item No. 44221

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-diethyl-4-methyl-1-piperazinecarboxamide, 2-hydroxy-1,2,3-propanetricarboxylate, monocitrate
CAS Number
1642-54-2
Synonyms
  • DEC
  • NSC 80513
Molecular Formula
C10H21N3O • C6H8O7
Formula Weight
391.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
O=C(CC(C(O)=O)(CC(O)=O)O)O.O=C(N1CCN(CC1)C)N(CC)CC
InChi Code
InChI=1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
PGNKBEARDDELNB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Diethylcarbamazine is an antifilarial agent.1,2 In vivo, diethylcarbamazine (100 mg/kg) reduces microfilaria levels in B. pahangi-infected athymic mice. Formulations containing diethylcarbamazine have been used in the treatment of lymphatic filariasis and loiasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maizels, R.M., and Denham, D.A. Diethylcarbamazine (DEC): Immunopharmacological interactions of an anti-filarial drug. Parasitology 105, S49-S60 (1992).

    2. Peixoto, C.A., and Silva, B.S. Anti-inflammatory effects of diethylcarbamazine: A review. Eur. J. Pharmacol. 734, 35-41 (2014).