An alkaloid with diverse biological activities
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Deserpidine

Item No. 44222

Product Insert (PDF)
Technical Information
Formal Name
(3β,16β,17α,18β,20α)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester
CAS Number
131-01-1
Synonyms
  • Canescine
  • 11-Desmethoxyreserpine
  • NSC 72138
  • Raunormine
  • Recanescine
Molecular Formula
C32H38N2O8
Formula Weight
578.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
COC([C@H]1[C@@]2([H])C[C@]3([H])C4=C(CCN3C[C@@]2([H])C[C@H]([C@@H]1OC)OC(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6N4)=O
InChi Code
InChI=1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,21+,23-,26-,27+,30+/m1/s1
InChi Key
CVBMAZKKCSYWQR-WCGOZPBSSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $171

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    25 mg

    $380

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    50 mg

    $665

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    Product Description

    Deserpidine is an alkaloid that has been found in R. canescens and a derivative of reserpine (Item No. 16474) that has diverse biological activities.1,2 Deserpidine (5 mg/kg) induces cardiac norepinephrine depletion and sedation in mice.1 It decreases blood pressure in dogs when administered at a dose of 0.5 mg/kg.2 Deserpidine also decreases heart rate and body temperature and induces miosis and diarrhea in rabbits and induces emesis in pigeons.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Creveling, C.R., Daly, J.W., Parfitt, R.T., et al. The chemorelease of norepinephrine from mouse hearts. IV. Structure-activity relationships. Reserpines and yohimbines. J. Med. Chem. 11(3), 596-598 (1968).

    2. Schneider, J.A., Plummer, A.J., Earl, A.E., et al. Pharmacological studies with deserpidine, a new alkaloid from Rauwolfia canescens. J. Pharmacol. Exp. Ther. 114(1), 10-13 (1955).