A sulfonamide antibiotic
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Alternative(s)
43465Mafenide (hydrochloride)
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Mafenide (acetate)

Item No. 44225

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(aminomethyl)-benzenesulfonamide, monoacetate
CAS Number
13009-99-9
Synonyms
  • p-Aminomethylbenzenesulfonamide
  • 4-Homosulfanilamide
  • Homosulfamine
  • Marfanil
  • Mesudin
Molecular Formula
C7H10N2O2S • C2H4O2
Formula Weight
246.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
O=C(C)O.NCC1=CC=C(S(N)(=O)=O)C=C1
InChi Code
InChI=1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)
InChi Key
UILOTUUZKGTYFQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Cayman Chemical
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    Product Description

    Mafenide is a sulfonamide antibiotic.1,2 It is active against clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 μg/ml.1 Mafenide is also active against clinical isolates of K. pneumoniae that produce extended spectrum β-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 μg/ml for all).2 It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa.3 Mafenide also inhibits human carbonic anhydrase I (CAI) and CAII (Kis = 41.91 and 0.612 μM, respectively).4 Formulations containing mafenide have been used in the treatment of bacterial infections associated with burn wounds.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rodgers, G.L., Mortensen, J.E., Fisher, M.C., et al. In vitro susceptibility testing of topical antimicrobial agents used in pediatric burn patients: Comparison of two methods. J. Burn Care Rehabil. 18(5), 406-410 (1997).

    2. Glasser, J.S., Guymon, C.H., Mende, K., et al. Activity of topical antimicrobial agents against multidrug-resistant bacteria recovered from burn patients. Burns 36(8), 1172-1184 (2010).

    3. Fox, C.L., Jr., Sampath, A.C., and Stanford, J.W. Virulence of Pseudomonas infection in burned rats and mice. Comparative efficacy of silver sulfadiazine and mafenide. Arch. Surg. 101(4), 508-512 (1970).

    4. Fidan, İ., Salmas, R.E., Arslan, M., et al. Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives. Bioorg. Med. Chem. 23(23), 7353-7358 (2015).