A bisphosphonate that inhibits bone resorption
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Tiludronate (sodium salt)

Item No. 44251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[[(4-chlorophenyl)thio]methylene]bis-phosphonic acid, disodium salt
CAS Number
149845-07-8
Synonyms
  • SR 41319
Molecular Formula
C7H7ClO6P2S • 2Na
Formula Weight
362.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=P(O)(C(P(O)([O-])=O)SC1=CC=C(C=C1)Cl)[O-].[Na+].[Na+]
InChi Code
InChI=1S/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
InChi Key
SKUHWSDHMJMHIW-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $125

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    50 mg

    $238

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    100 mg

    $325

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    Product Description

    Tiludronate is a bisphosphonate that inhibits bone resorption.1,2 It inhibits pit formation induced by primary mouse osteoclast-like multinucleated cells (OCLs) and decreases primary mouse OCL-induced increases in dentine resorption levels in dentine slices when used at a concentration of 100 µM.1 Tiludronate (300 µM) inhibits secretion of casein-degrading proteinase, proteoglycan-degrading proteinase, and collagenase induced by colony-stimulating factor (CSF) in primary rabbit synovial cells and chondrocytes.3 It decreases the erythrocyte sedimentation rate (ESR), a marker of inflammation, and hindlimb paw levels of prostaglandin E2 (PGE2) in a rat model of M. tuberculosis-induced arthritis. Tiludronate also reduces paw redness, swelling, and volume, and increases the latency to fall in the rotarod test in the same model.4 Formulations containing tiludronate have been used in the treatment of Paget's disease of bone.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murakami, H., Takahashi, N., Sasaki, T., et al. A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders. Bone 17(2), 137-144 (1995).

    2. Bell, N.H., and Johnson, R.H. Bisphosphonates in the treatment of osteoporosis. Endocrine 6(2), 203-206 (1997).

    3. Edmonds-Alt, X., Brelière, J.C., and Roncucci, R. Effects of 1-hydroxyethylidene-1,1 bisphosphonate and (chloro-4 phenyl) thiomethylene bisphosphonic acid (SR 41319) on the mononuclear cell factor-mediated release of neutral proteinases by articular chondrocytes and synovial cells. Biochem. Pharmacol. 34(22), 4043-4049 (1985).

    4. Barbier, A., Breliére, J.C., Remandet, B., et al. Studies on the chronic phase of adjuvant arthritis: Effect of SR 41319, a new diphosphonate. Ann. Rheum. Dis. 45(1), 67-74 (1986).