A hydroxy fatty acid

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Product Type

Lipids

Octadecanoids

Research Area

Cancer

Endocrinology & Metabolism

Microbiome

10(S)-hydroxy Stearic Acid

Name: 10(S)-hydroxy Stearic Acid
Brand: Cayman Chemical

Item No. 44258

10(S)-hydroxy Stearic Acid (FA 18:0;O, 10(S)-HODA, 10(S)-HSA, 10(S)-hydroxy ODA, 10(S)-Hydroxyoctadecanoic Acid, CAS Number: 67042-09-5)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

(S)-10-hydroxy-octadecanoic acid

CAS Number

67042-09-5

Synonyms

FA 18:0;O
10(S)-HODA
10(S)-HSA
10(S)-hydroxy ODA
10(S)-Hydroxyoctadecanoic Acid

Molecular Formula

C₁₈H₃₆O₃

Formula Weight

300.5

Purity

≥98%

Formulation

A solid

Solubility(Learn about Variance in Solubility)

DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml

SMILES

CCCCCCCC[C@H](O)CCCCCCCCC(O)=O

InChi Code

InChI=1S/C18H36O3/c1-2-3-4-5-8-11-14-17(19)15-12-9-6-7-10-13-16-18(20)21/h17,19H,2-16H2,1H3,(H,20,21)/t17-/m0/s1

InChi Key

PAZZVPKITDJCPV-KRWDZBQOSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

1 mg

$109

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5 mg

$464

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10 mg

$818

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Product Description

10(S)-hydroxy Stearic acid is a hydroxy fatty acid and minor metabolite of oleic acid (Item Nos. 90260 | 24659) formed by gut microbiota and other bacteria.^1,2 It inhibits the proliferation of A549 lung cancer and Caco-2 colon cancer cells when used at concentrations of 50 and 100 µM.³

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Serra, S., and De Simeis, D. Use of Lactobacillus rhamnosus (ATCC 53103) as whole-cell biocatalyst for the regio- and stereoselective hydration of oleic, linoleic, and linolenic acid. Catalysts 8(3), 109 (2018).

2. Yang, W., Dostal, L., and Rosazza, J.P. Stereospecificity of microbial hydrations of oleic acid to 10-hydroxystearic acid. Appl. Environ. Microb. 59(1), 281-284 (1993).

3. Kokotou, M.G., Kokotos, A.C., Gkikas, D., et al. Saturated hydroxy fatty acids exhibit a cell growth inhibitory activity and suppress the cytokine-induced β-cell apoptosis. J. Med. Chem. 63(21), 12666-12681 (2020).

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