An aldose reductase inhibitor
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AT-007

Item No. 44265

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-thieno[3,4-d]pyridazine-1-acetic acid
CAS Number
2170729-29-8
Synonyms
  • Goverestat
Molecular Formula
C17H10F3N3O3S2
Formula Weight
425.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(O)CC1=NN(CC2=NC3=C(S2)C=CC(C(F)(F)F)=C3)C(C4=CSC=C14)=O
InChi Code
InChI=1S/C17H10F3N3O3S2/c18-17(19,20)8-1-2-13-12(3-8)21-14(28-13)5-23-16(26)10-7-27-6-9(10)11(22-23)4-15(24)25/h1-3,6-7H,4-5H2,(H,24,25)
InChi Key
ORQGHAJIWGGFJK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $63

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    25 mg

    $149

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    50 mg

    $267

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    Product Description

    AT-007 is an inhibitor of aldose reductase (IC50 = 100 pM).1 It reduces high glucose-induced senescence in isolated human keratinocytes when used at a concentration of 0.2 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, Y., Lobato, A.G., Rebelo, A.P., et al. Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency. JCI Insight 8(10), e164954 (2023).

    2. Yepuri, G., Kancharla, K., Perfetti, R., et al. The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence. Front. Aging 5, 1466281 (2024).