A PDE6D molecular glue degrader
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TMX-4100

Item No. 44276

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-2,6-piperidinedione
CAS Number
2367619-63-2
Molecular Formula
C11H10N4O2S
Formula Weight
262.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(N1)C(N2N=NC(C3=CSC=C3)=C2)CCC1=O
InChi Code
InChI=1S/C11H10N4O2S/c16-10-2-1-9(11(17)12-10)15-5-8(13-14-15)7-3-4-18-6-7/h3-6,9H,1-2H2,(H,12,16,17)
InChi Key
PGEUBQZQGXWTFO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $274

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    10 mg

    $521

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    25 mg

    $1,028

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    50 mg

    $1,507

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    Product Description

    TMX-4100 is a molecular glue degrader of phosphodiesterase 6D (PDE6D).1 It promotes the interaction between the E3 ubiquitin ligase cereblon and PDE6D, inducing the degradation of PDE6D in MOLT-4 T cell lymphoblasts, Jurkat leukemia cells, and MM.1S multiple myeloma cells with half-maximal degradation concentration (DC50) values of <200 nM for all.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Teng, M., Lu, W., Donovan, K.A., et al. Development of PDE6D and CK1α degraders through chemical derivatization of FPFT-2216. J. Med. Chem. 65(1), 747-756 (2022).