An ionizable cationic lipid
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Lipid TD5

Item No. 44285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-(ditetradecylamino)hexyl]-1H-indole-3-propanamide
CAS Number
2855180-86-6
Molecular Formula
C45H81N3O
Formula Weight
680.2
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(CCC1=CNC2=C1C=CC=C2)NCCCCCCN(CCCCCCCCCCCCCC)CCCCCCCCCCCCCC
InChi Code
InChI=1S/C45H81N3O/c1-3-5-7-9-11-13-15-17-19-21-24-30-38-48(39-31-25-22-20-18-16-14-12-10-8-6-4-2)40-32-26-23-29-37-46-45(49)36-35-42-41-47-44-34-28-27-33-43(42)44/h27-28,33-34,41,47H,3-26,29-32,35-40H2,1-2H3,(H,46,49)
InChi Key
DJDVSUSUQPEWBX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $195

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    10 mg

    $351

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    25 mg

    $683

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    Cayman Chemical
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    Product Description

    Lipid TD5 is an ionizable cationic lipid (pKa = 7.3) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid TD5 undergo endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes. Intrathecal administration of LNPs containing lipid TD5 selectively traffic to the brain over the liver and spleen in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, Y., Wang, C., Li, H., et al. Lipid nanoparticles enhance mRNA delivery to the central nervous system upon intrathecal injection. Adv. Mater. 37(27), e2417097 (2025).