A Bcl-6 inhibitor
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OICR-12694

Item No. 44288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[5-(aminocarbonyl)-2,3-difluoro-4-hydroxyphenyl]-N-[3-chloro-6-[(2S)-2,4-dimethyl-1-piperazinyl]-2-fluoro-4-pyridinyl]-4,6,7,8-tetrahydro-4-oxo-1H-dipyrrolo[1,2-a:2′,3′-d]pyrimidine-1-acetamide
CAS Number
2360625-97-2
Synonyms
  • JNJ-65234637
Molecular Formula
C29H28ClF3N8O4
Formula Weight
645.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
NC(C(C=C1C2=CN(CC(NC3=C(Cl)C(F)=NC(N4CCN(C[C@@H]4C)C)=C3)=O)C5=C2C(N6CCCC6=N5)=O)=C(C(F)=C1F)O)=O
InChi Code
InChI=1S/C29H28ClF3N8O4/c1-13-10-38(2)6-7-40(13)19-9-17(22(30)26(33)36-19)35-20(42)12-39-11-16(14-8-15(27(34)44)25(43)24(32)23(14)31)21-28(39)37-18-4-3-5-41(18)29(21)45/h8-9,11,13,43H,3-7,10,12H2,1-2H3,(H2,34,44)(H,35,36,42)/t13-/m0/s1
InChi Key
LGAFZGSECXDYIR-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    OICR-12694 is an inhibitor of Bcl-6.1 It binds to the BTB domain on Bcl-6 (Kd = 5 nM in a surface plasmon resonance (SPR) assay). OICR-12694 decreases transcription of Bcl-6-targeted genes in a reporter assay using SU-DHL-4 cells (EC50 = 89 nM). It reduces the proliferation of Karpas-422 large B cell lymphoma cells (IC50 = 92 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mamai, A., Chau, A.M., Wilson, B.J., et al. Discovery of OICR12694: A novel, potent, selective, and orally bioavailable BCL6 BTB inhibitor. ACS Med. Chem. Lett. 14(2), 199-210 (2023).