An Mcl-1 inhibitor
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ABBV-467

Item No. 44289

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7R,16R)-19,23-dichloro-10-[[2-[4-[(2R)-1,4-dioxan-2-ylmethoxy]phenyl]-4-pyrimidinyl]methoxy]-1-(4-fluorophenyl)-7,8,15,16-tetrahydro-20,22-dimethyl-16-[(4-methyl-1-piperazinyl)methyl]-18,21-etheno-9,13-metheno-13H-6,14,17-trioxa-2-thia-3,5-diazacyclononadec[cd]indene-7-carboxylic acid
CAS Number
2287186-66-5
Molecular Formula
C53H51Cl2FN6O9S
Formula Weight
1038.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC(C(C1=C(C2=CC=C(C=C2)F)SC3=NC=NC(O[C@H](CC4=C(C=CC(OC[C@H](O5)CN6CCN(CC6)C)=C4)OCC7=NC(C8=CC=C(OC[C@@H]9OCCOC9)C=C8)=NC=C7)C(O)=O)=C13)=C%10C)=C(Cl)C5=C%10Cl
InChi Code
InChI=1S/C53H51Cl2FN6O9S/c1-30-43-31(2)47(55)48(46(30)54)70-39(24-62-18-16-61(3)17-19-62)27-68-38-12-13-41(69-25-36-14-15-57-50(60-36)33-6-10-37(11-7-33)67-28-40-26-65-20-21-66-40)34(22-38)23-42(53(63)64)71-51-45-44(43)49(72-52(45)59-29-58-51)32-4-8-35(56)9-5-32/h4-15,22,29,39-40,42H,16-21,23-28H2,1-3H3,(H,63,64)/t39-,40-,42-/m1/s1
InChi Key
BOMNURVTAHAEBQ-KWIIHVIGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $270

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    Cayman Chemical
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    Product Description

    ABBV-467 is an inhibitor of myeloid cell leukemia-1 (Mcl-1; Ki = <0.1 nM).1 It is selective for Mcl-1 over Bcl-2, Bcl-xL, Bcl-W, and Bcl-2-A1 (Kis = >642, >376, >247, and >402 nM, respectively). ABBV-467 reduces the viability of AMO1, NCI H929, and MV4-11 myeloma cells (EC50s = 0.16, 0.47, and 3.91 nM, respectively). In vivo, ABBV-467 (3.13, 6.25, and 12.5 mg/kg) reduces tumor growth in an AMO1 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yuda, J., Will, C., Phillips, D.C., et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun. Med. (Lond) 3(1), 154 (2023).