An inositol phosphate
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D-myo-Inositol-1,2,3,4,5,6-hexaphosphate (lithium salt)

Item No. 44296

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4,5,6-hexakis(dihydrogen phosphate)myo-inositol, hexalithium salt
Synonyms
  • IP6
  • Lithium Phytate
  • Phytic Acid
Molecular Formula
C6H12O24P6 • 6Li
Formula Weight
695.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=P(O[C@H]1[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1OP(O)([O-])=O)([O-])O.[Li+].[Li+].[Li+].[Li+].[Li+].[Li+]
InChi Code
InChI=1S/C6H17O24P6.6Li/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;/h1-6H,(H11-,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24);;;;;;/q;6*+1/p-5/t1-,2-,3-,4+,5-,6-;;;;;;
InChi Key
AYIYXIBFBFPPDE-BQYPOXACSA-I
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    D-myo-Inositol-1,2,3,4,5,6-hexaphosphate (IP6) is an inositol phosphate.1 It is ubiquitously found in eukaryotes.2 In mammalian cells, IP6 functions as a phosphate storage unit and is metabolized to differentially substituted inositol phosphates, each of which are necessary for cellular functions, including signal transduction, cell growth and differentiation, energy regulation, mRNA transcription, or DNA repair.2,3 It inhibits iron-induced increases in thiobarbituric acid reactive substances (TBARS) and hydroxyl radical levels and chelates iron when used at a concentration of 2 mM. IP6 (200 µM) induces apoptosis in HT-29, SW480, and SW620 colon cancer cells.4 Formulations containing IP6 have been used in cosmetics and as food preservatives.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Graf, E., Empson, K.L., and Eaton, J.W. Phytic acid. A natural antioxidant. The Journal of Biological Chemisty 262(14), 11647-11650 (1987).

    2. Shamsuddin, A.K., and Bose, S. IP6 (inositol hexaphosphate) as a signaling molecule. Curr. Signal Transduct. Ther. 7(3), 291 (2012).

    3. Vucenik, I. Anticancer properties of inositol hexaphosphate and inositol: An overview. J. Nutr. Sci. Vitaminol. (Tokyo) 65(Supplement), S18-S22 (2019).

    4. Schröterová, L., Hasková, P., Rudolf, E., et al. Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma. Oncol. Rep. 23(3), 787-793 (2010).