A CXCR7 agonist
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VUF 11207 (fumarate)

Item No. 44309

Product Insert (PDF)
Technical Information
Formal Name
N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, fumarate
Molecular Formula
C27H35FN2O4 • C4H4O4
Formula Weight
586.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(O)/C=C/C(O)=O.FC1=C(C=C(CN(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC3N(C)CCC3)C)C=CC=C1
InChi Code
InChI=1S/C27H35FN2O4.C4H4O4/c1-19(15-20-9-6-7-11-23(20)28)18-30(14-12-22-10-8-13-29(22)2)27(31)21-16-24(32-3)26(34-5)25(17-21)33-4;5-3(6)1-2-4(7)8/h6-7,9,11,15-17,22H,8,10,12-14,18H2,1-5H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChi Key
MTPOECCHJLVVGO-WLHGVMLRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $168

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    25 mg

    $347

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    50 mg

    $594

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    Product Description

    VUF 11207 is an agonist of chemokine (C-X-C motif) receptor 7 (CXCR7; EC50 = 1.6 nM in a β-arrestin recruitment assay).1 It also reduces CXCR7 cell surface expression in HEK293 cells expressing the human receptor (EC50 = 14.1 nM). VUF 11207 (5 nM) induces the migration and proliferation of primary human pericytes isolated from patients with pulmonary arterial hypertension.2 In vivo, VUF 11207 (5 mg/kg) increases thoracic adventitia thickness and aorta collagen deposition in a mouse model of hypertension induced by angiotensin II.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wijtmans, M., Maussang, D., Sirci, F., et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur. J. Med. Chem. 51, 184-192 (2012).

    2. Bordenave, J., Tu, L., Berrebeh, N., et al. Lineage tracing reveals the dynamic contribution of pericytes to the blood vessel remodeling in pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 40(3), 766-782 (2020).

    3. Song, B., Chen, D., Liu, Z., et al. Stromal cell-derived factor-1 exerts opposing roles through CXCR4 and CXCR7 in angiotensin II-induced adventitial remodeling. Biochem. Biophys. Res. Commun. 594, 38-45 (2022).