An ionizable cationic lipid
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4A3-SC10

Item No. 44320

Product Insert (PDF)
Technical Information
CAS Number
1857340-80-7
Synonyms
  • 4A3-SC-10
Molecular Formula
C83H155N3O16S4
Formula Weight
1579.4
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: Soluble: ≥10mg/ml
SMILES
O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCCCC)C)=O
InChi Code
InChI=1S/C83H155N3O16S4/c1-10-14-18-22-26-30-34-38-64-103-68-72(5)80(91)99-60-56-95-76(87)44-52-85(53-45-77(88)96-57-61-100-81(92)73(6)69-104-65-39-35-31-27-23-19-15-11-2)50-42-48-84(9)49-43-51-86(54-46-78(89)97-58-62-101-82(93)74(7)70-105-66-40-36-32-28-24-20-16-12-3)55-47-79(90)98-59-63-102-83(94)75(8)71-106-67-41-37-33-29-25-21-17-13-4/h72-75H,10-71H2,1-9H3
InChi Key
ZWVUGJXUQZRPGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $396

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    25 mg

    $805

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    Cayman Chemical
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    Product Description

    4A3-SC10 is an ionizable cationic lipid (pKa = 6.57) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing 4A3-SC10 selectively accumulate in the liver, kidney, and spleen in mice. LNPs containing 4A3-SC10 and encapsulating an mRNA reporter induce reporter expression in 4T1 breast cancer cells, B16/F10 melanoma cells, and AML12 hepatocytes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Z., Tian, Y., Yang, J., et al. Modular design of biodegradable ionizable lipids for improved mRNA delivery and precise cancer metastasis delineation in vivo. J. Am. Chem. Soc. 145(44), 24302-24314 (2023).