Podocarpic Acid

Podocarpic acid is a diterpenoid that has been found in D. cupressinum resins and has diverse biological activities.^1,2,3 It increases ionic currents in a patch-clamp assay using CHO-K1 cells expressing human large-conductance calcium-activated potassium channels (K_Ca1.1/BKα) when used at a concentration of 30 µM.¹ Podocarpic acid (20 µM) reduces hyperesthesia, neuronal damage, and increases lifespan in a model of α-dicarbonyl-related stress using C. elegans expressing a mutant form of the gene encoding glyoxylase 1.² It inhibits the infection of MDCK cells by influenza A virus (EC₅₀ = 18.2 µM).³ Podocarpic acid has also been used as a building block in the synthesis of podocarpic acid dimers, such as acetyl podocarpic acid anhydride (APD; Item No. 10007686), with liver X receptor (LXR) agonist activity.⁴

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1. Cui, Y.-M., Yasutomi, E., Otani, Y., et al. Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. Bioorg. Med. Chem. Lett. 18(19), 5197-5200 (2008).

2. Chaudhuri, J., Bose, N., Gong, J., et al. A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification. Curr. Biol. 26(22), 3014-3025 (2016).

3. Dang, Z., Jung, K., Zhu, L., et al. Phenolic diterpenoid derivatives as anti-influenza a virus agents. ACS Med. Chem. Lett. 6(3), 355-358 (2015).

4. Singh, S.B., Ondeyka, J.G., Liu, W., et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg. Med. Chem. Lett. 15(11), 2824-2828 (2005).