A malic enzyme inhibitor
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Malic Enzyme Inhibitor ME1

Item No. 44383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-2,5-pyrrolidinedione
CAS Number
522649-59-8
Molecular Formula
C20H21N3O3
Formula Weight
351.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
OC1=CC=C(N2CCN(C(C(N3C4=CC=CC=C4)=O)CC3=O)CC2)C=C1
InChi Code
InChI=1S/C20H21N3O3/c24-17-8-6-15(7-9-17)21-10-12-22(13-11-21)18-14-19(25)23(20(18)26)16-4-2-1-3-5-16/h1-9,18,24H,10-14H2
InChi Key
JJFJQFJFFVLMCX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $83

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    5 mg

    $269

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    10 mg

    $455

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    25 mg

    $929

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    Product Description

    Malic enzyme inhibitor ME1 is an inhibitor of malic enzyme (ME; IC50s = 0.22, 0.2, and 0.15 µM for ME1, ME2, and ME3, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sheth, G., Shah, S.R., Sengupta, P., et al. In the quest for potent and selective malic enzyme 3 inhibitors for the treatment of pancreatic ductal adenocarcinoma. ACS Med. Chem. Lett. 14(1), 41-50 (2022).