A copper chelator and neurotoxicant
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Cuprizone

Item No. 44456

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide)
CAS Number
370-81-0
Synonyms
  • CPZ
  • bis-Cyclohexanone oxaldihydrazone
  • bis(Cyclohexylidenehydrazide)
  • NSC 4283
Molecular Formula
C14H22N4O2
Formula Weight
278.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C(N/N=C1CCCCC/1)=O)N/N=C2CCCCC/2
InChi Code
InChI=1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
InChi Key
DSRJIHMZAQEUJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $49

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    50 g

    $88

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    100 g

    $157

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    250 g

    $343

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    Product Description

    Cuprizone is a copper chelator and neurotoxicant.1 It is selectively cytotoxic to mature differentiated primary rat oligodendrocytes over SH-SY5Y neuroblastoma cells and primary rat microglia, astrocytes, and oligodendrocyte precursor cells at 500 µM. Cuprizone has commonly been used to induce demyelination in mouse models of demyelinating diseases, such as multiple sclerosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bénardais, K., Kotsiari, A., Skuljec, J., et al. Cuprizone [bis(cyclohexylidenehydrazide)] is selectively toxic for mature oligodendrocytes. Neurotox. Res. 24(2), 244-250 (2013).

    2. Zhan, J., Mann, T., Joost, S., et al. The cuprizone model: Dos and do nots. Cells 9(4), 843 (2020).