An inhibitor of mutant K-Ras
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BI-2493

Item No. 44474

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4′S)-2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile
CAS Number
2937344-16-4
Molecular Formula
C24H27N7OS
Formula Weight
461.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
N#CC1=C(N)SC2=C1[C@]3(CCC2)C4=C(CCC3)C(C5=NC(N6[C@H](CNCC6)C)=NC=C5)=NO4
InChi Code
InChI=1S/C24H27N7OS/c1-14-13-27-10-11-31(14)23-28-9-6-17(29-23)20-15-4-2-7-24(21(15)32-30-20)8-3-5-18-19(24)16(12-25)22(26)33-18/h6,9,14,27H,2-5,7-8,10-11,13,26H2,1H3/t14-,24-/m0/s1
InChi Key
PVOYBVVIBNPTPJ-BSEYFRJRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $520

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    Cayman Chemical
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    Product Description

    BI-2493 is an inhibitor of mutant K-Ras.1 It selectively decreases the proliferation of Ba/F3 cells expressing K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C), K-RasG12D, or K-RasG12V (EC50s = 118, 52, and 81 nM, respectively) over Ba/F3 cells expressing H-Ras or N-Ras (EC50s = 2,359 and 1,576 nM, respectively). BI-2493 (30 mg/kg twice per day) reduces tumor volume in SW480 colon adenocarcinoma and NCI H358 non-small cell lung cancer (NSCLC) mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bröker, J., Waterson, A.G., Hodges, T.R., et al. Discovery of BI-2493, a pan-KRAS inhibitor showing in vivo efficacy. J. Med. Chem. 68(15), 15649-15668 (2025).