A citrulline-containing decapeptide
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Poly Citrulline (acetate)

Item No. 44481

Technical Information
Formal Name
(6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-1,6-diamino-1,7,10,13,16,19,22,25,28,31-decaoxo-9,12,15,18,21,24,27,30,33-nonakis(3-ureidopropyl)-2,8,11,14,17,20,23,26,29,32-decaazatetratriacontan-34-oic acid, acetate
Synonyms
  • Cit-Cit-Cit-Cit-Cit-Cit-Cit-Cit-Cit-Cit-OH
  • Decacitrulline
Molecular Formula
C60H112N30O21 • XC2H4O2
Formula Weight
Purity
≥98%
A solid
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=O)N
InChi Code
InChI=1S/C60H112N30O21/c61-31(11-1-21-72-51(62)102)41(91)82-32(12-2-22-73-52(63)103)42(92)83-33(13-3-23-74-53(64)104)43(93)84-34(14-4-24-75-54(65)105)44(94)85-35(15-5-25-76-55(66)106)45(95)86-36(16-6-26-77-56(67)107)46(96)87-37(17-7-27-78-57(68)108)47(97)88-38(18-8-28-79-58(69)109)48(98)89-39(19-9-29-80-59(70)110)49(99)90-40(50(100)101)20-10-30-81-60(71)111/h31-40H,1-30,61H2,(H,82,91)(H,83,92)(H,84,93)(H,85,94)(H,86,95)(H,87,96)(H,88,97)(H,89,98)(H,90,99)(H,100,101)(H3,62,72,102)(H3,63,73,103)(H3,64,74,104)(H3,65,75,105)(H3,66,76,106)(H3,67,77,107)(H3,68,78,108)(H3,69,79,109)(H3,70,80,110)(H3,71,81,111)/t31-,32-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
InChi Key
IKILMDZFRBGSED-QMAXXTOWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Poly citrulline is a citrulline-containing decapeptide. It has been used as a hapten in the generation of anti-citrulline antibodies, which have been used to detect citrullination in postmortem human brain samples and synovial biopsy samples from patients with rheumatoid arthritis.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nicholas, A.P., and Whitaker, J.N. Preparation of a monoclonal antibody to citrullinated epitopes: Its characterization and some applications to immunohistochemistry in human brain. Glia 37(4), 328-336 (2002).

    2. Makrygiannakis, D., Revu, S., Engström, M., et alLocal administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis. Arthritis Res. Ther. 14(1), R20 (2012).