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Poly citrulline is a citrulline-containing decapeptide. It has been used as a hapten in the generation of anti-citrulline antibodies, which have been used to detect citrullination in postmortem human brain samples and synovial biopsy samples from patients with rheumatoid arthritis.1,2
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1. Preparation of a monoclonal antibody to citrullinated epitopes: Its characterization and some applications to immunohistochemistry in human brain. Glia 37(4), 328-336 (2002).
2. Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis. Arthritis Res. Ther. 14(1), R20 (2012).