A peptide fragment of RHAU
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RHAU 23 (trifluoroacetate salt)

Item No. 44485

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-L-prolylglycyl-L-histidyl-L-leucyl-L-lysylglycyl-L-arginyl-L-α-glutamyl-L-isoleucylglycyl-L-methionyl-L-tryptophyl-L-tyrosyl-L-alanyl-L-lysyl-L-lysyl-L-glutaminylglycyl-L-glutaminyl-L-lysyl-L-asparaginyl-L-lysine, trifluoroacetate salt
Synonyms
  • RHAU (53-75) (human)
Molecular Formula
C120H191N39O30S • XCF3COOH
Formula Weight
2692.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
HPGHLKGREIGMWYAKKQGQKNK-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Soluble: ≥10mg/ml
SMILES
O=C(N1CCC[C@H]1C(NCC(N[C@@H](CC2=CN([H])C=N2)C(N[C@H](C(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC(O)=O)C(N[C@@](C(NCC(N[C@@H](CCSC)C(N[C@@H](CC3=CN([H])C4=C3C=CC=C4)C(N[C@@H](CC5=CC=C(O[H])C=C5)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N[H])=O)C(NCC(N[C@@H](CCC(N[H])=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N[H])=O)C(N[C@@H](CCCCN[H])C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)[C@H](CC6=CN([H])C=N6)N[H].O=C(O)C(F)(F)F
InChi Code
InChI=1S/C120H191N39O30S.C2HF3O2/c1-7-66(4)100(158-110(179)83(37-40-99(168)169)152-104(173)77(29-20-47-134-120(130)131)143-95(164)59-136-102(171)76(24-10-15-42-121)148-112(181)86(50-65(2)3)154-114(183)89(54-71-58-133-64-141-71)146-98(167)61-138-116(185)91-30-21-48-159(91)118(187)74(126)53-70-57-132-63-140-70)117(186)139-62-97(166)145-84(41-49-190-6)109(178)156-88(52-69-56-135-75-23-9-8-22-73(69)75)113(182)155-87(51-68-31-33-72(160)34-32-68)111(180)142-67(5)101(170)147-78(25-11-16-43-122)105(174)149-79(26-12-17-44-123)106(175)151-81(35-38-92(127)161)103(172)137-60-96(165)144-82(36-39-93(128)162)108(177)150-80(27-13-18-45-124)107(176)157-90(55-94(129)163)115(184)153-85(119(188)189)28-14-19-46-125;3-2(4,5)1(6)7/h8-9,22-23,31-34,56-58,63-67,74,76-91,100,135,160H,7,10-21,24-30,35-55,59-62,121-126H2,1-6H3,(H2,127,161)(H2,128,162)(H2,129,163)(H,132,140)(H,133,141)(H,136,171)(H,137,172)(H,138,185)(H,139,186)(H,142,180)(H,143,164)(H,144,165)(H,145,166)(H,146,167)(H,147,170)(H,148,181)(H,149,174)(H,150,177)(H,151,175)(H,152,173)(H,153,184)(H,154,183)(H,155,182)(H,156,178)(H,157,176)(H,158,179)(H,168,169)(H,188,189)(H4,130,131,134);(H,6,7)/t66-,67-,74-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-;/m0./s1
InChi Key
PKXMZUSPLLNVRM-LHNBABBTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $116

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    10 mg

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    25 mg

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    Product Description

    RHAU 23 is a peptide fragment of RNA helicase associated with AU-rich element protein (RHAU).1,2 RHAU peptide fragments have been incorporated into peptide-peptide nucleic acid (PNA) conjugates and detection and pull-down probes to stabilize bimolecular guanine-quadruplexes (G4s) and capture G4 structures in vitro, respectively.3,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Basak, S., Biswas, S., and Naskar, J. Peptides and peptide derivatives as G-quadruplex targeting ligands: A brief review. ChemistrySelect 8(34), e202302177 (2023).

    2. Wen, C.J., Gong, J.Y., Zheng, K.W., et al. Targeting nucleic acids with a G-triplex-to-G-quadruplex transformation and stabilization using a peptide-PNA G-tract conjugate. Chem. Commun. (Camb.) 56(48), 6567-6570 (2020).

    3. Zheng, K.-W., Zhang, J.-Y., He, Y.-D., et al. Detection of genomic G-quadruplexes in living cells using a small artificial protein. Nucleic Acids Res. 48(20), 11706-11720 (2020).