A citrullinated peptide derivative of filaggrin
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CCP (trifluoroacetate salt)

Item No. 44486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((4R,7S,13S,16S,19S,25S,28S,31S,34S,37S,40S,43R)-40-((1H-imidazol-4-yl)methyl)-43-((S)-5-amino-2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)-5-oxopentanamido)-37-(3-amino-3-oxopropyl)-34-(2-carboxyethyl)-7,13,19-tris(3-guanidinopropyl)-28-((R)-1-hydroxyethyl)-16,31-bis(hydroxymethyl)-6,9,12,15,18,21,24,27,30,33,36,39,42-tridecaoxo-25-(3-ureidopropyl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35,38,41-tridecaazacyclotetratetracontane-4-carbonyl)glycyl-L-arginyl-L-serylglycyl-L-seryl-L-lysine-2,2,2-trifluoroacetic acid
Synonyms
  • Citrullinated Filaggrin (Q447H, S449C, G459R, E460G, S462C, S468K) (R455) (447-468) (cyclized)
  • Cyclic Citrullinated Peptide
Molecular Formula
C93H157N43O33S2 • XCF3COOH
Formula Weight
2469.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
HQ[CHQESTXGRSRGRC]GRSGSK-OH (X=citrulline)
Solubility(Learn about Variance in Solubility)
DMSO: Slightly Soluble: 0.1-1 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]1CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)N.O=C(C(F)(F)F)O
InChi Code
InChI=1S/C93H157N43O33S2.C2HF3O2/c1-43(141)70-87(166)128-48(11-8-26-113-93(106)169)73(152)115-32-65(144)121-50(13-6-24-111-91(102)103)77(156)132-59(37-139)84(163)125-47(10-4-22-109-89(98)99)72(151)114-31-66(145)122-51(14-7-25-112-92(104)105)78(157)134-61(75(154)117-33-67(146)120-49(12-5-23-110-90(100)101)76(155)131-57(35-137)74(153)116-34-68(147)123-58(36-138)83(162)129-55(88(167)168)9-2-3-21-94)39-170-171-40-62(135-81(160)52(15-18-63(96)142)124-71(150)46(95)27-44-29-107-41-118-44)86(165)130-56(28-45-30-108-42-119-45)82(161)127-53(16-19-64(97)143)79(158)126-54(17-20-69(148)149)80(159)133-60(38-140)85(164)136-70;3-2(4,5)1(6)7/h29-30,41-43,46-62,70,137-141H,2-28,31-40,94-95H2,1H3,(H2,96,142)(H2,97,143)(H,107,118)(H,108,119)(H,114,151)(H,115,152)(H,116,153)(H,117,154)(H,120,146)(H,121,144)(H,122,145)(H,123,147)(H,124,150)(H,125,163)(H,126,158)(H,127,161)(H,128,166)(H,129,162)(H,130,165)(H,131,155)(H,132,156)(H,133,159)(H,134,157)(H,135,160)(H,136,164)(H,148,149)(H,167,168)(H4,98,99,109)(H4,100,101,110)(H4,102,103,111)(H4,104,105,112)(H3,106,113,169);(H,6,7)/t43-,46+,47+,48+,49+,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,70+;/m1./s1
InChi Key
LNNWIBOFIDAMTR-XYGMRQBWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Cyclic citrullinated peptide (CCP) is a cyclic peptide that corresponds to amino acids 447-468 of human filaggrin but contains Q447H, S449C, G459R, E460G, S462C, and S468K substitutions and is citrullinated at arginine 455. This product can be used in the detection of anti-citrulline autoantibodies.

    WARNING This product is not for human or veterinary use.