A biotinylated version of Rab-22A
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cancer
Cell Signaling
GTPases

Biotin-Rab-22A (1-10) (trifluoroacetate salt)

Item No. 44490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,5R,8S,11S,14S,17S)-11-(4-aminobutyl)-17-((2S,5S,8S,11S)-2-(3-guanidinopropyl)-5-isobutyl-8-methyl-11-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9,12-tetraazaheptadecanamido)-2,14-diisobutyl-8-isopropyl-5-(mercaptomethyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosanedioic acid, trifluoroacetate salt
Molecular Formula
C63H109F3N16O17S3 • XCF3COOH
Formula Weight
1515.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Biotin-MALRELKVCL-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C([C@@H](NC(CCCC[C@H]1[C@]([C@](CS1)(NC2=O)[H])(N2)[H])=O)CCSC)N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CS)=O)C(C)C)=O)CCCCN)=O)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)=O.FC(C(O)=O)(F)F
InChi Code
InChI=1S/C61H108N16O15S3.C2HF3O2/c1-31(2)26-40(71-50(81)35(9)66-51(82)39(22-25-94-10)67-46(78)19-12-11-18-45-49-44(30-95-45)75-61(92)77-49)55(86)69-37(17-15-24-65-60(63)64)52(83)70-38(20-21-47(79)80)53(84)72-41(27-32(3)4)56(87)68-36(16-13-14-23-62)54(85)76-48(34(7)8)58(89)74-43(29-93)57(88)73-42(59(90)91)28-33(5)6;3-2(4,5)1(6)7/h31-45,48-49,93H,11-30,62H2,1-10H3,(H,66,82)(H,67,78)(H,68,87)(H,69,86)(H,70,83)(H,71,81)(H,72,84)(H,73,88)(H,74,89)(H,76,85)(H,79,80)(H,90,91)(H4,63,64,65)(H2,75,77,92);(H,6,7)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,48-,49-;/m0./s1
InChi Key
YWZWLBPYNUPJDU-KXUNREILSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $45

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    10 mg

    $86

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    25 mg

    $203

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    50 mg

    $360

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    Cayman Chemical
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    Product Description

    Biotin-Rab-22A (1-10) is a biotinylated version of the GTPase Ras-related protein Rab-22A that corresponds to residues 1-10 of human and mouse Rab-22A.1 It inhibits RhoA-GTP increases induced by Rab-22A (1-38) or an oncogenic Rab-22A fusion protein Rab-22A-NeoF1 in 143B whole cell lysates.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liao, D., Zhong, L., Yin, J., et al. Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma. Nat. Cell Biol. 22(7), 868-881 (2020).