An inhibitor of ADP/ATP translocases
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Atractyloside (potassium salt)

Item No. 44522

Product Insert (PDF)
Technical Information
Formal Name
(2β)-15α-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic acid, potassium salt
CAS Number
695179-73-8
Molecular Formula
C30H46O16S2 • XK
Formula Weight
726.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O[C@@H]1[C@]23[C@](CC[C@](C1=C)([H])C3)([H])[C@]4([C@]([C@@H](C[C@H](C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)OS(=O)(O)=O)OS(=O)(O)=O)OC(CC(C)C)=O)C(O)=O)([H])CC2)C.[K]
InChi Code
InChI=1S/C30H46O16S2.K/c1-14(2)9-22(32)44-25-24(46-48(39,40)41)23(45-47(36,37)38)20(13-31)43-28(25)42-17-10-18(27(34)35)19-7-8-30-11-16(15(3)26(30)33)5-6-21(30)29(19,4)12-17;/h14,16-21,23-26,28,31,33H,3,5-13H2,1-2,4H3,(H,34,35)(H,36,37,38)(H,39,40,41);/t16-,17-,18-,19-,20-,21+,23-,24+,25-,26+,28-,29-,30-;/m1./s1
InChi Key
DMODBUNAAVVOKD-FLPKXFLTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $45

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    5 mg

    $214

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    10 mg

    $405

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    25 mg

    $900

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    Product Description

    Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera.1 Atractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dahout-Gonzalez, C., Hury, H., Trézéguet, V., et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-249 (2006).

    2. Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochim. Biophys. Acta 1778(10), 1978-2021 (2008).