An inhibitor of ABHD18
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ABD646

Item No. 44548

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-((4-(methylsulfonyl)benzyl)oxy)-3-(4-(trifluoromethyl)benzyl)-1,3,4-oxadiazol-2(3H)-one
Molecular Formula
C18H15F3N2O5S
Formula Weight
428.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C1OC(OCC2=CC=C(S(=O)(C)=O)C=C2)=NN1CC3=CC=C(C(F)(F)F)C=C3
InChi Code
InChI=1S/C18H15F3N2O5S/c1-29(25,26)15-8-4-13(5-9-15)11-27-16-22-23(17(24)28-16)10-12-2-6-14(7-3-12)18(19,20)21/h2-9H,10-11H2,1H3
InChi Key
OYDYQXBJLGIHAN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $68

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    5 mg

    $306

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    10 mg

    $476

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    Product Description

    ABD646 is an inhibitor of α/β-hydrolase domain-containing protein 18 (ABHD18).1 It reduces ABHD18 activity in a mass spectrometry activity-based protein profiling (MS-ABPP) analysis using a 1:1 mixture of THP-1:COLO 205 cell lysates at 1 and 10 µM. ABD646 reduces the ratio of monolysocardiolipin to cardiolipin (MLCL:CL) in HAP1 tafazzin-knockout cells when used at a concentration of 5 µM. It also reduces the MLCL:CL ratio, improves mitochondrial respiratory chain activity, and improves mitochondrial morphology in skin fibroblasts derived from patients with Barth syndrome, an X-linked disorder associated with mutations in TAFAZZIN. ABD646 (1 µM) improves heart morphology in tafazzin-deficient zebrafish embryos.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Masud, S.N., Srivastava, A., Mero, P., et al. Genetic suppression features ABHD18 as a Barth syndrome therapeutic target. Nature 645(8082), 1029-1038 (2025).