An iridoid valepotriate with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Acevaltrate

Item No. 44641

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(acetyloxy)-3-methyl-butanoic acid, (1S,2′R,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1-(3-methyl-1-oxobutoxy)spiro[cyclopenta[c] pyran-7(1H),2′-oxiran]-6-yl ester
CAS Number
25161-41-5
Molecular Formula
C24H32O10
Formula Weight
480.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
[H][C@]1([C@@]2(CO2)[C@@H](OC(CC(C)(OC(C)=O)C)=O)C=C1C(COC(C)=O)=CO3)[C@@H]3OC(CC(C)C)=O
InChi Code
InChI=1S/C24H32O10/c1-13(2)7-19(27)33-22-21-17(16(11-30-22)10-29-14(3)25)8-18(24(21)12-31-24)32-20(28)9-23(5,6)34-15(4)26/h8,11,13,18,21-22H,7,9-10,12H2,1-6H3/t18-,21+,22-,24+/m0/s1
InChi Key
FWKBQAVMKVZEOT-STCFVSJZSA-N
Origin
Plant/Valeriana officinalis L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $29

    Add

    5 mg

    $94

    Add

    10 mg

    $160

    Add

    25 mg

    $326

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Acevaltrate is an iridoid valepotriate that has been found in V. glechomifolia and has diverse biological activities.1,2,3 It inhibits Na+/K+-ATPase in isolated rat kidney that endogenously expresses this transporter (IC50 = 22.8 µM) and H+/K+-ATPase activity by 60.7% in isolated rat gastric epithelium, which endogenously expresses H+/K+-ATPase, when used at a concentration of 100 µM.2 Acevaltrate (1-4 µM) induces pyroptosis in OCI-My5 and OPM-2 multiple myeloma cells.3 It increases the production of reactive oxygen species (ROS), inhibits glutathione peroxidase 4 (GPX4), and induces ferroptosis in RKO colon cancer cells when used at a concentration of 5 µM.1 In vivo, acevaltrate (10, 25, and 50 mg/kg) reduces tumor volume and increases intratumoral malondialdehyde (MDA) levels in an RKO mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, D., Hu, H., Zhang, Q., et al. Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer. Signal Transduct. Target Ther. 10(1), 211 (2025).

    2. Bettero, G.M., Salles, L., Rosário Figueira, R.M., et al. In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases. Planta Med. 77(15), 1702-1706 (2011).

    3. Wang, Y., Cui, Y., Liu, Z., et al. Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria. Eur. J. Pharmacol. 996, 177572 (2025).