A PI3K/Akt/mTOR pathway inhibitor
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PI3K/Akt/mTOR-IN-2

Item No. 44655

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3,5-difluorophenyl)-1,3,4,9-tetrahydro-pyrano[3,4-b]indole
CAS Number
2757804-89-8
Synonyms
  • Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin-IN-2
  • Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Inhibitor 2
Molecular Formula
C17H13F2NO
Formula Weight
285.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
FC1=CC(C2OCCC3=C2NC4=C3C=CC=C4)=CC(F)=C1
InChi Code
InChI=1S/C17H13F2NO/c18-11-7-10(8-12(19)9-11)17-16-14(5-6-21-17)13-3-1-2-4-15(13)20-16/h1-4,7-9,17,20H,5-6H2
InChi Key
XBYJYKHTEFYLFX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    100 mg

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    Product Description

    PI3K/Akt/mTOR-IN-2 is an inhibitor of the PI3K/Akt/mTOR pathway.1 It reduces the phosphorylation of Akt and mTOR when used at a concentration of 2 µM and decreases PI3K, Akt, and mTOR levels at 4 µM. PI3K/Akt/mTOR-IN-2 is cytotoxic to A549, BGC-823, PC3, MCF-7, and MDA-MB-231 cancer cells (IC50s = 14.81, 9.11, 9.04, 7.89, and 2.29 µM, respectively). It induces apoptosis and cell cycle arrest at the G0/G1 phase in MDA-MB-231 breast cancer cells. PI3K/Akt/mTOR-IN-2 decreases the mitochondrial membrane potential and glutathione (GSH) levels and increases reactive oxygen species (ROS) and intracellular calcium levels in MDA-MB-231 cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qin, J., Sun, X., Ma, Y., et al. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway. Bioorg. Med. Chem. 55, 116594 (2022).