A peptide-dye conjugate for the visualization of intact and degenerated nerves
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Bevonescein (trifluoroacetic acid)

Item No. 44659

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[(3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H) 9′-[9H]xanthen]-5-yl)carbonyl]-L-glutaminyl-L-valyl-L-prolyl-L-trypto phyl-L-α-glutamyl-L-α-glutamyl-L-prolyl-L-tyrosyl-L-tyrosyl-L-valyl-Lvalyl-L-lysyl-L-lysyl-L-seryl-L-serylglycyl-glycinamide
Synonyms
  • ALM-488
Molecular Formula
C112H144N22O32 • XCF3COOH
Formula Weight
2310.5
Purity
≥95%
Emission
530 nm
Excitation
488 nm
Formulation (Request formulation change)
A solid
Peptide Sequence
5-FAM-QVPWEEPYYVVKKSSGG-NH2
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1OC(C(C(O2)=C3)=CC=C3O)(C(C2=C4)=CC=C4O)C(C1=C5)=CC=C5C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N(CCC6)[C@@H]6C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N(CCC7)[C@@H]7C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C=C8)=CC=C8O)=O)CC(C=C9)=CC=C9O)=O)=O)=O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C112H144N22O32.C2HF3O2/c1-56(2)92(107(160)123-74(18-10-12-42-114)97(150)121-73(17-9-11-41-113)98(151)129-82(55-136)104(157)128-81(54-135)96(149)119-53-89(143)118-52-88(116)142)131-108(161)93(57(3)4)130-103(156)79(46-60-23-28-64(138)29-24-60)125-101(154)78(45-59-21-26-63(137)27-22-59)126-105(158)83-19-13-43-133(83)109(162)77(37-40-91(146)147)124-99(152)76(36-39-90(144)145)122-102(155)80(48-62-51-117-72-16-8-7-15-67(62)72)127-106(159)84-20-14-44-134(84)110(163)94(58(5)6)132-100(153)75(35-38-87(115)141)120-95(148)61-25-32-69-68(47-61)111(164)166-112(69)70-33-30-65(139)49-85(70)165-86-50-66(140)31-34-71(86)112;3-2(4,5)1(6)7/h7-8,15-16,21-34,47,49-51,56-58,73-84,92-94,117,135-140H,9-14,17-20,35-46,48,52-55,113-114H2,1-6H3,(H2,115,141)(H2,116,142)(H,118,143)(H,119,149)(H,120,148)(H,121,150)(H,122,155)(H,123,160)(H,124,152)(H,125,154)(H,126,158)(H,127,159)(H,128,157)(H,129,151)(H,130,156)(H,131,161)(H,132,153)(H,144,145)(H,146,147);(H,6,7)/t73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,92-,93-,94-;/m0./s1
InChi Key
YWJTWGLSNDQMSH-LKUJRGPDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Bevonescein is a peptide-dye conjugate for the visualization of intact and degenerated nerves.1 It is composed of a synthetic 17-amino acid peptide conjugated to 5-carboxy fluorescein (5-FAM; Item No. 19581) and displays excitation/emission maxima of 488/530 nm.2,3 Bevonescein (900 nmol/animal) has been used to identify degenerated nerves via real-time fluorescence imaging in mice in a model of facial nerve transection.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crawford, K.L., Lee, Y.-J., Hom, M., et al. Identification of degenerated murine facial nerves with fluorescence labeling after transection injury. Otolaryngol. Head Neck Surg. 169(2), 234-242 (2023).

    2. Lee, Y.J., Orosco, R.K., Bouvet, M., et al. Intraoperative nerve-specific fluorescence visualization in head and neck surgery: A Phase 1 trial. Nat. Commun. 16(1), 6060 (2025).

    3. Azari, F., Zhang, K., Kennedy, G.T., et al. Precision surgery guided by intraoperative molecular imaging. J. Nucl. Med. 63(11), 1620-1627 (2022).