For immunochemical detection of mertansine conjugates
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Mertansine Monoclonal Antibody (Clone 2D12)

Item No. 44707

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • DM1
  • Drug Maytansinoid 1
  • Emtansine
Immunogen
Mertansine-KLH
Clone Designation
2D12
Formulation (Request formulation change)
200 µg of protein G-purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG1λ
Applications
ELISA, WB
Cross Reactivity
(+) Mertansine(-) MMAE
Species Reactivity
(+) Independent
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $385

    Add
    Cayman Chemical
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    Product Description

    Mertansine is a semisynthetic maytansinoid antimitotic agent.1,2 It disrupts mitotic spindle formation and induces cell cycle arrest and cell death in cancer cells in vitro. Mertansine has commonly been used as a payload in antibody-drug conjugates (ADCs), which have been used to selectively target and destroy cancer cells in vitro and in vivo.3,4,5 Formulations containing mertansine conjugated to ado-trastuzumab have been used in the treatment of HER2+ breast cancer. Cayman’s Mertansine Monoclonal Antibody (Clone 2D12) can be used for ELISA and Western blot applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Widdison, W.C., Wilhelm, S.D., Cavanagh, E.E., et al. Semisynthetic maytansine analogues for the targeted treatment of cancer. J. Med. Chem. 49(14), 4392-4408 (2006).

    2. Lopus, M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 307(2), 113-115 (2011).

    3. Berdeja, J.G. Lorvotuzumab mertansine: Antibody-drug-conjugate for CD56+ multiple myeloma. Front. Biosci. 19(1), 163-170 (2014).

    4. Mckertish, C.M., and Kayser, V. A novel dual-payload ADC for the treatment of HER2+ breast and colon cancer. Pharmaceutics 15(8), 2020 (2023).

    5. Huhe, M., Lou, J., Zhu, Y., et al. A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer. Biochem. Biophys. Res. Commun. 513(4), 1083-1091 (2019).