A click chemistry building block
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TCO-PEG4-NHS ester

Item No. 44735

Product Insert (PDF)
Technical Information
Formal Name
5,8,11,14-tetraoxa-2-azaheptadecanedioic acid, 1-(4E)-4-cycloocten-1-yl 17-(2,5-dioxo-1-pyrrolidinyl) ester
CAS Number
1621096-79-4
Synonyms
  • trans-Cyclooctene-PEG4-N-hydroxysuccinimide
Molecular Formula
C24H38N2O10
Formula Weight
514.6
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥ 10 mg/ml
SMILES
O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC2CC/C=C/CCC2
InChi Code
InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1+
InChi Key
ZKPMRASGLDBKPF-OWOJBTEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    TCO-PEG4-NHS ester is a click chemistry building block.1 It has been used as a starting material in the synthesis of HELIOS-based fluorescent probes and radiotracers for in vivo imaging of bombesin receptor subtype 2-expressing prostate cancer mouse xenograft models.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meimetis, L.G., Carlson, J.C.T., Giedt, R.J., et al. Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging. Angew Chem. Int. Ed. Engl. 53(29), 7531-7534 (2014).

    2. Handula, M., Verhoeven, M., Chen, K.T., et al. Towards complete tumor resection: Novel dual-modality probes for improved image-guided surgery of GRPR-expressing prostate cancer. Pharmaceutics 14(1), 195 (2022).