A fungal secondary metabolite with antiviral activity
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Penisimplicissin

Item No. 44760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6-dimethoxy-3R-(6-methyl-4-oxo-4H-pyran-3-yl)-1(3H)-isobenzofuranone
CAS Number
873207-55-7
Molecular Formula
C16H14O6
Formula Weight
302.3
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
COC1=C2[C@H](C3=COC(C)=CC3=O)OC(C2=CC(OC)=C1)=O
InChi Code
InChI=1S/C16H14O6/c1-8-4-12(17)11(7-21-8)15-14-10(16(18)22-15)5-9(19-2)6-13(14)20-3/h4-7,15H,1-3H3/t15-/m0/s1
InChi Key
FKFNGBPZNWNWSG-HNNXBMFYSA-N
Origin
Fungus/Talaromyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Penisimplicissin is a fungal secondary metabolite that has been found in T. pinophilus and has antiviral activity.1 It increases cell viability, induces increases in aryl hydrocarbon receptor (AhR) levels, a marker of viral infection, and decreases in viral nuclear protein levels in a reporter cell line using canine coronavirus-infected A-72 cells when used a concentration of 0.5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cerracchio, C., Salvatore, M.M., Del Sorbo, L., et al. In vitro evaluation of antiviral activities of funicone-like compounds vermistatin and penisimplicissin against canine coronavirus infection. Antibiotics (Basel) 12(8), 1319 (2023).