A fungal metabolite with anticancer activity
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Isomer(s)
11328Cytochalasin B
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Product Categories

Product Type

Biochemicals
Natural Products
Microbial Metabolites

Research Area

Cancer

Cytochalasin Z2

Item No. 44761

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3E,5R,9R,11E,12aS,15S,15aS,16S,18aR)-6,7,8,9,10,12a,15,15a,16,17-decahydro-5-hydroxy-14-(hydroxymethyl)-9,15-dimethyl-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
CAS Number
450398-31-9
Molecular Formula
C29H37NO5
Formula Weight
479.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C1[C@]23[C@]([C@@H](C(CO)=C[C@]2([H])/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(O3)=O)C)([H])[C@@H](N1)CC4=CC=CC=C4
InChi Code
InChI=1S/C29H37NO5/c1-19-8-6-12-23-17-22(18-31)20(2)27-25(16-21-10-4-3-5-11-21)30-28(34)29(23,27)35-26(33)15-14-24(32)13-7-9-19/h3-6,10-12,14-15,17,19-20,23-25,27,31-32H,7-9,13,16,18H2,1-2H3,(H,30,34)/b12-6+,15-14+/t19-,20+,23-,24+,25-,27-,29+/m0/s1
InChi Key
NRBGZVXIBNDMCT-GVENNPLOSA-N
Origin
Fungi/Drechslera sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 µg

    $129

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    1 mg

    $464

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    Cayman Chemical
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    Product Description

    Cytochalasin Z2 is a fungal metabolite that has been found in P. semeniperda and has anticancer activity.1 It inhibits the growth of OE21 esophageal squamous cell carcinoma, U373 MG glioblastoma, A549 lung cancer, B16/F10 melanoma, and Hs 683 glioma cancer cells (IC50s = 70, 86, 99, 29, and 94 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Goietsenoven, G., Mathieu, V., Andolfi, A., et al. In vitro growth inhibitory effects of cytochalasins and derivatives in cancer cells. Planta Med. 77(7), 711-717 (2011).