A fungal metabolite with anti-germination activity
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Product Categories

Product Type

Natural Products
Microbial Metabolites
Polyketides

Research Area

Plant Biology

Hancockiamide C

Item No. 44771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2S,5S)-4-acetyl-2-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-5-(phenylmethyl)-1-piperazinyl]-3-phenyl-2E-propen-1-one
CAS Number
2758265-36-8
Molecular Formula
C31H32N2O5
Formula Weight
512.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(N(C[C@@H](N(C(C)=O)C1)CC2=CC=CC=C2)[C@H]1CC3=CC4=C(OCO4)C(OC)=C3)/C=C/C5=CC=CC=C5
InChi Code
InChI=1S/C31H32N2O5/c1-22(34)32-19-27(16-25-17-28(36-2)31-29(18-25)37-21-38-31)33(20-26(32)15-24-11-7-4-8-12-24)30(35)14-13-23-9-5-3-6-10-23/h3-14,17-18,26-27H,15-16,19-21H2,1-2H3/b14-13+/t26-,27-/m0/s1
InChi Key
RVLALFABWNVGIS-HKRYAFHYSA-N
Origin
Fungus/Aspergillus hancockii
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 µg

    $139

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    1 mg

    $473

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    Product Description

    Hancockiamide C is an N-cinnamoylated piperazine fungal metabolite that has been found in A. hancockii and has anti-germination activity.1 It inhibits germination in a seed assay using the dicotyledon species A. thaliana (MIC = 6.3 µg/ml) but not the monocotyledon species E. tef at 100 µg/ml.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, H., Lacey, A.E., Shu, S., et al. Hancockiamides: Phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway. Org. Biomol. Chem. 19(3), 587-595 (2021).