An ellagitannin with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Thonningianin A

Item No. 44802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-[[4,6-O-[[(1S)-4,4′,5,5′,6,6′-hexahydroxy[1,1′-biphenyl]-2,2′-diyl]dicarbonyl]-3-O-(3,4,5-trihydroxybenzoyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-phenyl-1-propanone
CAS Number
271579-11-4
Molecular Formula
C42H34O21
Formula Weight
874.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=C(O)C=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](COC3=O)O2)OC(C4=CC(O)=C(O)C(O)=C4C5=C(O)C(O)=C(O)C=C53)=O)OC(C6=CC(O)=C(O)C(O)=C6)=O)O)C=C1O)CCC7=CC=CC=C7
InChi Code
InChI=1S/C42H34O21/c43-20(7-6-15-4-2-1-3-5-15)30-21(44)10-17(11-22(30)45)60-42-36(55)38(63-39(56)16-8-23(46)31(50)24(47)9-16)37-27(61-42)14-59-40(57)18-12-25(48)32(51)34(53)28(18)29-19(41(58)62-37)13-26(49)33(52)35(29)54/h1-5,8-13,27,36-38,42,44-55H,6-7,14H2/t27-,36-,37-,38-,42-/m1/s1
InChi Key
XQVKQEFQGYTUAR-VHBRHXFYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $55

    Add

    5 mg

    $138

    Add

    10 mg

    $193

    Add

    25 mg

    $413

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Thonningianin A is an ellagitannin originally isolated from T. sanguinea that has diverse biological activities.1,2,3 It reduces lipid peroxidation and reactive oxygen species (ROS) formation and prevents reductions in glutathione peroxidase 4 (GPX4) activity, nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, and cell viability in PC12 cells induced by RSL-3 (Item No. 19288), a ferroptosis inducer.1 In vivo, thonningianin A reduces amyloid-β (Aβ) and phosphorylated tau protein levels and inhibits neuronal death and glial activation in a 3xTg mouse model of Alzheimer's disease.2 It is also active against the fungus C. albicans (MIC = 1 µg/ml).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yong, Y., Yan, L., Wei, J., et al. A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer’s disease by activating GPX4. Theranostics 14(16), 6161-6184 (2024).

    2. Yu, L., Wang, H., Yao, Q., et al. Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer’s disease-related β-amyloid and Tau proteins. Phytother. Res. 38(9), 4815-4831 (2024).

    3. Wang, H.L., H., Liu, Z., Zhu, Z., et al. Activity of thonningianin A against Candida albicans in vitro and in vivo. Appl. Microbiol. Biotechnol. 108(1), 96 (2024).