A peptide fusion tag
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FcIII Peptide (trifluoroacetate salt)

Item No. 44809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-cysteinyl-L-alanyl-L-tryptophyl-L-histidyl-L-leucylglycyl-L-α-glutamyl-L-leucyl-L-valyl-L-tryptophyl-L-cysteinyl-L-threonine, cyclic (2→12)-disulfide, trifluoroacetate salt
Molecular Formula
C69H95N17O19S2 • XCF3COOH
Formula Weight
1530.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
D[CAWHLGELVWC]T-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CSSC[C@H](NC([C@H](CC(O)=O)N)=O)C(N[C@@H](C)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CN=CN4)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H]1CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C69H95N17O19S2.C2HF3O2/c1-32(2)19-46-60(95)74-28-53(88)77-45(17-18-54(89)90)61(96)80-47(20-33(3)4)65(100)85-56(34(5)6)68(103)82-49(22-38-26-73-44-16-12-10-14-41(38)44)63(98)84-52(67(102)86-57(36(8)87)69(104)105)30-107-106-29-51(83-59(94)42(70)24-55(91)92)66(101)76-35(7)58(93)78-48(21-37-25-72-43-15-11-9-13-40(37)43)62(97)81-50(64(99)79-46)23-39-27-71-31-75-39;3-2(4,5)1(6)7/h9-16,25-27,31-36,42,45-52,56-57,72-73,87H,17-24,28-30,70H2,1-8H3,(H,71,75)(H,74,95)(H,76,101)(H,77,88)(H,78,93)(H,79,99)(H,80,96)(H,81,97)(H,82,103)(H,83,94)(H,84,98)(H,85,100)(H,86,102)(H,89,90)(H,91,92)(H,104,105);(H,6,7)/t35-,36+,42-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-;/m0./s1
InChi Key
AWNLGQJGMIVJCI-MRJNCTGSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    FcIII peptide is a synthetic, cyclic 13-amino acid peptide and fusion tag.1,2,3 It inhibits binding of the protein A Z domain to IgG Fc with a Ki value of 25 nM.4 FcIII peptide can be added to the N- or C-terminus of a protein and has been used as an epitope tag on recombinant proteins to facilitate their detection and purification.2,3 The inclusion of FcIII peptide on recombinant proteins also increases their plasma half-life in mice.2 FcIII peptide has also been used as a building block in the synthesis of artificial human Fc receptors to facilitate IgG uptake in Jurkat cells, which do not intrinsically express Fc receptors.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DeLano, W.L., Ultsch, M.H., de Vos, A.M., et al. Convergent solutions to binding at a protein-protein interface. Science 287(5456), 1279-1283 (2000).

    2. Sockolosky, J.T., Kivimäe, S., and Szoka, F.C. Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice. PLoS One 9(7), e102566 (2014).

    3. Feng, S., Tian, E., Zhang, L., et al. Development of the Fc-III tagged protein expression system for protein purification and detection. PLos One 7(8), e44208 (2012).

    4. Frey, J.R., Peck, R., and Bollag, W. Antiproliferative activity of retinoids, interferon α and their combination in five human transformed cell lines. Cancer Lett. 57(3), 223-227 (1991).

    5. Boonyarattanakalin, S., Martin, S.E., Sun, Q., et al. A synthetic mimic of human Fc receptors: Defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G. J. Am. Chem. Soc. 128(35), 11463-11470 (2006).