A nitric oxide donor
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Isosorbide Dinitrate

Item No. 44834

Product Insert (PDF)
Technical Information
Formal Name
1,4:3,6-dianhydro-D-glucitol, 2,5-dinitrate
CAS Number
87-33-2
Synonyms
  • ISDN
  • NSC 80038
Molecular Formula
C6H8N2O8
Formula Weight
236.1
Purity
≥98%
Formulation (Request formulation change)
A solid (stabilized with 60% lactose)
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
[H][C@@]1([C@@H](O[N+]([O-])=O)CO2)[C@@]2([H])[C@H](O[N+]([O-])=O)CO1
InChi Code
InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1
InChi Key
MOYKHGMNXAOIAT-JGWLITMVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.1,2 It induces vasodilation in norepinephrine-precontracted rabbit femoral vein and arterial strips with IC50 values of 0.56 and 1.82 µM, respectively.2 Isosorbide dinitrate (0.1 and 0.2 mg/kg) increases oxygenation of tumor tissue in vivo in a transplantable mouse liver tumor model.3 It also enhances inhibition of platelet aggregation induced by prostaglandin I2 (PGI2; Item No. 18220) in vitro.4 Formulations containing isosorbide dinitrate have been used in the prevention of angina pectoris due to coronary artery disease. This product is stabilized with 60% lactose.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahlner, J., Andersson, R.G., Torfgard, K., et al. Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol. Rev. 43(3), 351-423 (1991).

    2. Toyoda, J., Hisayama, T., and Takayanagi, I. Nitro compounds (isosorbide dinitrate, 5-isosorbide mononitrate and glyceryl trinitrate) on the femoral vein and femoral artery. Gen. Pharmacol. 17(1), 89-91 (1986).

    3. Jordan, B.F., Misson, P., Demeure, R., et al. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI. Int. J. Radiat. Oncol. Biol. Phys. 48(2), 565-570 (2000).

    4. De Caterina, R., Giannessi, D., Bernini, W., et al. Organic nitrates: Direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. Thromb. Haemost. 59(2), 207-211 (1988).