A cereblon modulator
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TD-106

Item No. 44836

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(5-amino-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2,6-piperidinedione
CAS Number
2250288-69-6
Molecular Formula
C12H11N5O3
Formula Weight
273.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1NC(C(CC1)N2C(C3=C(N=N2)C=CC=C3N)=O)=O
InChi Code
InChI=1S/C12H11N5O3/c13-6-2-1-3-7-10(6)12(20)17(16-15-7)8-4-5-9(18)14-11(8)19/h1-3,8H,4-5,13H2,(H,14,18,19)
InChi Key
DXZBHVQOULDEPN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $175

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    10 mg

    $315

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    25 mg

    $525

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    50 mg

    $875

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    Cayman Chemical
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    Product Description

    TD-106 is a modulator of cereblon.1 It binds to cereblon in a cellular thermal shift assay (CETSA) using HEK293 cells. TD-106 (1-1,000 nM) induces degradation of the cereblon targets Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in NCI H929 multiple myeloma cells and is cytotoxic to NCI H929 cells (CC50 = 0.039 µM). It also reduces tumor growth in a TMD8 diffuse large B cell lymphoma (DLBCL) mouse xenograft model when administered at a dose of 50 mg/kg per day. TD-106 has been used in the synthesis of proteolysis-targeting chimeras (PROTACs) with anticancer activity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, S.A., Go, A., Jo, S.H., et al. A novel cereblon modulator for targeted protein degradation. Eur. J. Med. Chem. 166, 65-74 (2019).