A DDX9 inhibitor
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ATX968

Item No. 44842

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-chloro-5-[(methylsulfonyl)amino]phenyl]-4-(3-methyl-2-pyridinyl)-2-thiophenecarboxamide
CAS Number
2973395-71-8
Synonyms
  • DHX9-IN-2
  • DHX9 Inhibitor 2
Molecular Formula
C18H16ClN3O3S2
Formula Weight
421.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
CC1=C(C2=CSC(C(NC3=CC(Cl)=CC(NS(C)(=O)=O)=C3)=O)=C2)N=CC=C1
InChi Code
InChI=1S/C18H16ClN3O3S2/c1-11-4-3-5-20-17(11)12-6-16(26-10-12)18(23)21-14-7-13(19)8-15(9-14)22-27(2,24)25/h3-10,22H,1-2H3,(H,21,23)
InChi Key
VDGNPEFFHQRGOP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $79

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    10 mg

    $95

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    25 mg

    $198

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    50 mg

    $356

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    Cayman Chemical
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    Product Description

    ATX968 is an inhibitor of DEAD-box helicase 9 (DDX9; IC50 = 8 nM for helicase activity).1 It is selective for DDX9 over DDX36, Brahma homolog (BRM), also known as SMARCA2, and Werner syndrome protein (WRN; IC50s = >10, >10, and >100 µM, respectively), as well as a panel of 96 kinases at 10 µM but does inhibit dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B). ATX968 (1 µM) selectively induces unresolved nuclear R-loop accumulation in microsatellite instable-high with deficient mismatch repair (MSI-H/dMMR) LS411N colorectal carcinoma cells over microsatellite-stable with proficient mismatch repair (MSS/pMMR) NCI H747 colorectal carcinoma cells. It induces tumor regression in an LS411N mouse xenograft model when administered at a dose of 300 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Castro, J., Daniels, M.H., Brennan, D., et al. A potent, selective, small-molecule inhibitor of DHX9 abrogates proliferation of microsatellite instable cancers with deficient mismatch repair. Cancer Res. 85(4), 758-776 (2025).