A probe for use in APEX2 proximity labeling
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Alkyne-phenol

Item No. 44843

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(4-hydroxyphenyl)ethyl]-4-pentynamide
CAS Number
1694495-59-4
Molecular Formula
C13H15NO2
Formula Weight
217.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(CCC#C)NCCC1=CC=C(C=C1)O
InChi Code
InChI=1S/C13H15NO2/c1-2-3-4-13(16)14-10-9-11-5-7-12(15)8-6-11/h1,5-8,15H,3-4,9-10H2,(H,14,16)
InChi Key
CQZJBJSXQYZLEX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $29

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    10 mg

    $46

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    25 mg

    $73

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    50 mg

    $116

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    Product Description

    Alkyne-phenol is a probe for APEX2 proximity labeling.1 In proximity labeling assays, alkyne-phenol is acted on by APEX2, an engineered peroxidase that catalyzes the generation of a free radical on the phenolic oxygen, forming a compound that reacts with molecules within a 10-20 nm radius. The alkyne moiety of this compound can be conjugated to azide-tagged fluorophores to label the proximity target. Alkyne-phenol has been used for proximity labeling of RNA in bacteria.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yassine, H., Sirotkin, E., Goldberger, O., et al. APEX2 proximity labeling of RNA in bacteria. Cell Rep. Methods 5(11), 101206 (2025).