An Rv2780 inhibitor
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GWP-042

Item No. 44848

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-N-[3-[(3-fluorophenyl)methyl]-1H-1,2,4-triazol-5-yl]tetrahydro-2-furancarboxamide
CAS Number
1645486-93-6
Molecular Formula
C14H15FN4O2
Formula Weight
290.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C([C@@H]1CCCO1)NC2=NN=C(N2)CC3=CC(F)=CC=C3
InChi Code
InChI=1S/C14H15FN4O2/c15-10-4-1-3-9(7-10)8-12-16-14(19-18-12)17-13(20)11-5-2-6-21-11/h1,3-4,7,11H,2,5-6,8H2,(H2,16,17,18,19,20)/t11-/m0/s1
InChi Key
MIWAYZPDMAOTDL-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $185

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    10 mg

    $293

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    25 mg

    $585

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    Cayman Chemical
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    Product Description

    GWP-042 is an inhibitor of the mycobacterial alanine dehydrogenase and virulence factor Rv2780 (IC50 = 0.21 µM).1 It inhibits the production of the antimicrobial peptides β-defensin-4 and cathelicidin antimicrobial peptide (Camp) and reduces intracellular survival of M. tuberculosis in isolated and infected mouse peritoneal macrophages, but does not inhibit the growth of M. tuberculosis in a host cell-free assay. In vivo, GWP-042 (10 mg/kg per day) reduces lung bacterial burden in M. tuberculosis-infected mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, C., Cheng, Y., Ma, M., et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat. Commun. 15(1), 4216 (2024).