A Wnt pathway inhibitor intended for use in cell, gene, and tissue engineering applications
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Alternative(s)
44886GMP IWR-1-endo Ancillary Material
Research Tool(s)
13659IWR-1-endo
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IWR-1-endo Ancillary Material

Item No. 44879

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide
CAS Number
1127442-82-3
Molecular Formula
C25H19N3O3
Formula Weight
409.4
Purity
≥98%
Formulation
An amorphous solid
SMILES
O=C(N(C(C=C1)=CC=C1C(NC2=CC=CC3=C2N=CC=C3)=O)C4=O)[C@]5([H])[C@@]4([H])[C@@H]6C=C[C@H]5C6
InChi Code
InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
InChi Key
ZGSXEXBYLJIOGF-ALFLXDJESA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Ambient in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $399

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    Product Description

    IWR-1-endo is an inhibitor of the Wnt signaling pathway that acts via inhibition of tankyrases and stabilization of axin.1,2 It has been used to maintain proliferation of hematopoietic stem cells, promote pluripotency of human embryonic stem cells, and induce differentiation of progenitor cells.3,4,5 IWR-1-endo Ancillary Material is intended for use in cell, gene, and tissue engineering applications.

    This product has been tested in accordance with GMP principles and meets the expectations for clinical cell, gene, and tissue-engineered products in accordance with USP <1043> “Ancillary Materials for Cell, Gene, and Tissue-engineered Products”.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, B., Dodge, M.E., Tang, W., et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5(2), 100-107 (2009).

    2. Huang, S.M.A., Mishina, Y.M., Liu, S., et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461, 614-619 (2009).

    3. Kimura, K., Yamamori, S., Hazawa, M., et al. Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem Cells 40(9), 831-842 (2022).

    4. Choi, H., Oh, D., Kim, M., et al. Establishment of procine embryonic stem cells in simplified serum free media and feeder free espansion. Stem Cell Res. Ther. 15(1), 245 (2024).

    5. Ito, A., Ye, K., Onda, M., et al. Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells. Biochem. Biophys. Res. Commun. 552, 66-72 (2021).

    6.  &lt;1043> Ancillary materials for cell, gene, and tissue-engineered products. (2025).