Inhibitor of γ-secretase
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13197DAPT
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DAPT Ancillary Material

Item No. 44882

Product Insert (PDF)
Technical Information
Formal Name
N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine, 1,1-dimethylethyl ester
CAS Number
208255-80-5
Synonyms
  • GSI-IX
  • LY-374973
Molecular Formula
C23H26F2N2O4
Formula Weight
432.5
Purity
≥98%
Formulation (Request formulation change)
An amorphous solid
SMILES
C[C@@H](C(N[C@@H](C1=CC=CC=C1)C(OC(C)(C)C)=O)=O)NC(CC2=CC(F)=CC(F)=C2)=O
InChi Code
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChi Key
DWJXYEABWRJFSP-XOBRGWDASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $559

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    Product Description

    DAPT is an inhibitor of γ-secretase, blocking the production of total Aβ in human primary neuronal cultures with an IC50 value of 115 nM and Aβ42 with an IC50 value of 200 nM.1 Through its effects on γ-secretase, DAPT indirectly inhibits Notch, affecting cell signaling and cell differentiation.2,3 DAPT Ancillary Material is intended for use in cell, gene, and tissue engineering applications.

    This product has been tested in accordance with GMP principles and meets the expectations for clinical cell, gene, and tissue-engineered products in accordance with USP <1043> “Ancillary Materials for Cell, Gene, and Tissue-engineered Products”.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dovey, H.F., John, V., Anderson, J.P., et al. Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. J. Neurochem. 76(1), 173-181 (2001).

    2. Kanungo, J., Zheng, Y.L., Amin, N.D., et al. The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins. J. Neurochem. 106, 2236-2248 (2008).

    3. De Smedt, M., Hoebeke, I., Reynvoet, K., et al. Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. Blood 106(10), 3498-3506 (2005).

    4.  <1043> Ancillary materials for cell, gene, and tissue-engineered products. (2025).