A methoxylated bibenzyl with anticancer activity
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Product Type

Biochemicals
Natural Products

Research Area

Cancer
Cell Death
Multidrug Resistance

Brittonin A

Item No. 44901

Product Insert (PDF)
Technical Information
Formal Name
1,1′-(1,2-ethanediyl)bis[3,4,5-trimethoxy-benzene
CAS Number
33284-74-1
Synonyms
  • 1,2-Bis(3,4,5-trimethoxyphenyl)ethane
  • NSC 600172
Molecular Formula
C20H26O6
Formula Weight
362.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=C(C(OC)=CC(CCC2=CC(OC)=C(OC)C(OC)=C2)=C1)OC
InChi Code
InChI=1S/C20H26O6/c1-21-15-9-13(10-16(22-2)19(15)25-5)7-8-14-11-17(23-3)20(26-6)18(12-14)24-4/h9-12H,7-8H2,1-6H3
InChi Key
UHUDTHVLRMAKJZ-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $117

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    10 mg

    $215

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    25 mg

    $444

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    Cayman Chemical
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    Product Description

    Brittonin A is a methoxylated bibenzyl that has been found in the liverwort F. inouei and has anticancer activity.1 It is cytotoxic to KB and vincristine-resistant KB/VCR cells (IC50s = 42.1 and 33.7 µM, respectively), as well as K562 and adriamycin-resistant K562/A02 cells (IC50s = 49.6 and 30.9 µM, respectively). Brittonin A (5 µM) increases vincristine-induced cell death in KB/VCR cells and adriamycin-induced cell death in K562/A02 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, D.X., Xiang, F., Wang, X.N., et al. Labdane diterpenoids and highly methoxylated bibenzyls from the liverwort Frullania inouei. Phytochemistry 71(13), 1573-1578 (2010).