An ionizable cationic lipid
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AMG 1541

Item No. 44932

Product Insert (PDF)
Technical Information
Formal Name
(1,4,7,10,13,16-hexaazacyclooctadecane-1,4,7,10,13,16-hexayl)hexakis(2-hydroxypropane-3,1-diyl) (5Z,5'Z,5''Z,5'''Z,5''''Z,5'''''Z)-hexakis(dodec-5-enoate)
CAS Number
3092408-38-0
Molecular Formula
C102H186N6O18
Formula Weight
1784.6
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥ 10 mg/ml
SMILES
CCCCCC/C=C\CCCC(OCC(O)CN1CCN(CCN(CCN(CCN(CCN(CC1)CC(O)COC(CCC/C=C\CCCCCC)=O)CC(O)COC(CCC/C=C\CCCCCC)=O)CC(O)COC(CCC/C=C\CCCCCC)=O)CC(O)COC(CCC/C=C\CCCCCC)=O)CC(O)COC(CCC/C=C\CCCCCC)=O)=O
InChi Code
InChI=1S/C102H186N6O18/c1-7-13-19-25-31-37-43-49-55-61-97(115)121-85-91(109)79-103-67-69-104(80-92(110)86-122-98(116)62-56-50-44-38-32-26-20-14-8-2)71-73-106(82-94(112)88-124-100(118)64-58-52-46-40-34-28-22-16-10-4)75-77-108(84-96(114)90-126-102(120)66-60-54-48-42-36-30-24-18-12-6)78-76-107(83-95(113)89-125-101(119)65-59-53-47-41-35-29-23-17-11-5)74-72-105(70-68-103)81-93(111)87-123-99(117)63-57-51-45-39-33-27-21-15-9-3/h37-48,91-96,109-114H,7-36,49-90H2,1-6H3/b43-37-,44-38-,45-39-,46-40-,47-41-,48-42-
InChi Key
VVNZJBZUSOWDSM-OHHWYPJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $79

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    5 mg

    $316

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    10 mg

    $593

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    Product Description

    AMG 1541 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing AMG 1541 accumulate in the muscle or liver after intramuscular or intravenous administration, respectively, in mice. AMG 1541-containing LNPs encapsulating hemagglutinin A (HA) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein mRNA increase serum levels of binding antibody titers in mice 35 days post-vaccination. LNPs containing AMG 1541 and encapsulating HA mRNA elicit similar serum levels of neutralizing antibodies in mice as LNPs containing SM-102 (Item No. 33474) but with 100-fold less HA mRNA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rudra, A., Gupta, A., Reed, K., et al. Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines. Nat. Nanotechnol. 20(12), 1831-1842 (2025).