Host: Insect cells • AA: 53-306 • Tag: N-terminal His • MW: 30.3 kDa
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ABHD10 (human, recombinant)

Item No. 44968

Product Insert (PDF)
Technical Information
Synonyms
  • Abhydrolase Domain-containing 10
  • Acyl-protein Thioesterase ABHD10
  • α/β-Hydrolase Domain-containing Protein 10
  • Mitochondrial
  • Mycophenolic Acid Acyl-glucuronide Esterase
  • Palmitoyl-protein Thioesterase ABHD10, Mitochondrial
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU per g of the protein as determined by the LAL method
Source
Recombinant human N-terminal His-tagged ABHD10 expressed in insect cells
Amino Acids
53-306
MW
30.3 kDa
Formulation (Request formulation change)
Lyophilized from sterile 20 mM Tris, pH 8.0, with 500 mM sodium chloride and 10% glycerol
Host
Insect cells
UniProt Accession №
Q9NUJ1
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $348

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    Product Description

    α/β-Hydrolase domain-containing protein 10 (ABHD10) is an S-depalmitoylase, a deglucuronidase, and a member of the metabolic serine hydrolase family.1,2,3,4 It is composed of an N-terminal mitochondrial localization signal and ABHD fold that contains the Ser-His-Asp catalytic triad.3,4 ABHD10 is expressed in testis and liver and localizes to the mitochondria.4,1,2 It is involved in redox homeostasis via regulation of peroxiredoxin-5 (Prx5) palmitoylation and mitochondrial sheath formation via regulation of spermatogenesis-associated protein 19 (SPATA19), glycerol kinase 2 (GK2), and pyruvate dehydrogenase protein X component (PDHX) palmitoylation.3,4 ABHD10 is also involved in deglucuronidation of mycophenolic acid acyl glucuronide and probenecid acyl glucuronide in the liver.1,2 Knockout of Abhd10 induces sperm motility defects in mice.4 Liver expression of ABHD10 is decreased in patients with severe alcoholic hepatitis.5 Cayman’s ABHD10 (human, recombinant) protein consists of 271 amino acids and has a calculated molecular weight of 30.3 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 32 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwamura, A., Fukami, T., Higuchi, R., et al. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. The Journal of Biological Chemisty 287(12), 9240-9249 (2012).

    2. Ito, Y., Fukami, T., Yokoi, T., et al. An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver. Drug Metab. Dispos. 42(12), 2109-2116 (2014).

    3. Cao, Y., Qiu, T., Kathayat, R.S., et al. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Nat. Chem. Biol. 15(12), 1232-1240 (2019).

    4. Zhou, S., Zhou, H., Xu, H., et al. The S-depalmitoylase ABHD10 is essential for sperm mitochondrial sheath formation and male fertility. Nat. Commun. 16(1), 10334 (2025).

    5. Li, T.Z., Bai, C.Y., Wu, B., et al. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Commun. Biol. 6(1), 382 (2023).