Host: Insect cells • AA: 1-342 (full length) • Tag: N-terminal His • MW: 41 kDa
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ABHD4 (human, recombinant)

Item No. 44970

Product Insert (PDF)
Technical Information
Synonyms
  • Abhydrolase Domain-containing Protein 4
  • α/β-Hydrolase 4
  • α/β Hydrolase Domain-containing Protein 4
  • (Lyso)-N-Acylphosphatidylethanolamine Lipase
Purity
≥82% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/μg, determined by the LAL endotoxin assay
Source
Recombinant human N-terminal His-tagged ABHD4 expressed in insect cells
Amino Acids
1-342 (full length)
MW
41 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris, with 100 mM sodium chloride, 10% glycerol, and pH 8.0
UniProt Accession №
Q8TB40
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $348

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    Product Description

    α/β-Hydrolase domain-containing protein 4 (ABHD4) is a serine hydrolase and lysophospholipase/phospholipase B that hydrolyzes N-acyl phosphatidylethanolamines (NAPEs) and lyso-NAPEs.1,2 It is expressed in the brain, spinal cord, testes, liver, kidney, and heart.2 Abhd4-/- mice exhibit decreased brain levels of various N-acyl phospholipids, including plasmalogen-based lyso-NAPEs, N-acyl lysophosphatidylserines, and glycerophospho-N-acylethanolamines (GP-NAEs).1 Cayman’s ABHD4 (human, recombinant) protein consists of 360 amino acids and has a calculated molecular weight of 41 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, H.-C., Simon, G.M., and Cravatt, B.F. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry 54(15), 2539-2549 (2015).

    2. Simon, G.M., and Cravatt, B.F. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for α/β-hydrolase 4 in this pathway. The Journal of Biological Chemisty 281(36), 26465-26472 (2006).