Host: E. coli • AA: 1-210 (full length) • Tag: N-terminal His • MW: 24.2 kDa
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ABHD14B (human, recombinant)

Item No. 44971

Product Insert (PDF)
Technical Information
Synonyms
  • Abhydrolase Domain-containing 14B
  • α/β-Hydrolase Domain-containing Protein 14B
  • CCG1-interacting Factor B
  • CCG1/TAFII250-interacting Factor B
  • CCG1/TAF(II)250-interacting Factor B
  • CIB
  • Putative Protein-lysine Deacylase ABHD14B
Purity
≥96% estimated by SDS-PAGE
Source
Recombinant human N-terminal His-tagged ABHD14B expressed in E. coli
Amino Acids
1-210
MW
24.2 kDa
Formulation (Request formulation change)
Sterile PBS, pH 7.4, with 20% glycerol, 50 mM arginine, and 0.1% polysorbate 20
UniProt Accession №
Q96IU4
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $348

    Add
    Cayman Chemical
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    Product Description

    α/β-Hydrolase domain-containing protein 14B (ABHD14B) is a lysine deacetylase and member of the metabolic serine hydrolase family.1,2 It is composed of an ABHD fold that contains the Ser-His-Asp catalytic triad. ABHD14B is expressed in kidney, liver, and lung and localizes to the cytosol and nucleus. It transfers an acetyl group from acetylated lysines on proteins, such as histones, to CoA to produce acetyl-CoA.1,3 ABHD14B is involved in the regulation of glycolysis and the citric acid cycle, as well as viral transcription from hepatitis B virus (HBV) covalently closed circular DNA (cccDNA).2,3 Decreased expression of ABHD14B is associated with poor prognosis in patients with breast cancer.4 Cayman’s ABHD14B (human, recombinant) protein consists of 225 amino acids and has a calculated molecular weight of 24.2 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 24 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rajendran, A., Vaidya, K., Mendoza, J., et al. Functional annotation of ABHD14B, an orphan serine hydrolase enzyme. Biochemistry 59(2), 183-196 (2020).

    2. Rajendran, A., Soory, A., Khandelwal, N., et al. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals. The Journal of Biological Chemisty 298(7), 102128 (2022).

    3. Sekiba, K., Miyake, N., Miyakawa, Y., et al. CRISPR-mediated proximity labeling unveils ABHD14B as a host factor to regulate HBV cccDNA transcriptional activity. Hepatol. Commun. 9(8), e0757 (2025).

    4. Aushev, V.N., Gopalakrishnan, K., Teitelbaum, S.L., et al. Tumor expression of environmental chemical-responsive genes and breast cancer mortality. Endocr. Relat. Cancer 26(12), 843-851 (2019).