An ionizable cationic lipid for LNP brain targeting
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Lipid S4 (hydrochloride)

Item No. 44984

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
di(octan-3-yl) 9,9'-((6-((1-(6-chloropyridin-2-yl)piperidin-4-yl)amino)-6-oxohexyl)azanediyl)dinonanoate, monohydrochloride
Molecular Formula
C50H89ClN4O5 • HCl
Formula Weight
898.2
Purity
≥90%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-1 mg/ml
SMILES
ClC1=CC=CC(N2CCC(NC(CCCCCN(CCCCCCCCC(OC(CC)CCCCC)=O)CCCCCCCCC(OC(CC)CCCCC)=O)=O)CC2)=N1.Cl
InChi Code
InChI=1S/C50H89ClN4O5.ClH/c1-5-9-20-29-44(7-3)59-49(57)34-23-15-11-13-17-25-38-54(39-26-18-14-12-16-24-35-50(58)60-45(8-4)30-21-10-6-2)40-27-19-22-33-48(56)52-43-36-41-55(42-37-43)47-32-28-31-46(51)53-47;/h28,31-32,43-45H,5-27,29-30,33-42H2,1-4H3,(H,52,56);1H
InChi Key
BEQPSSOATPCHEX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $96

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    5 mg

    $384

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    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

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    Product Description

    Lipid S4 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 It contains SR-527227 (Item No. 35499), a ligand for the serotonin (5-HT) receptor subtype 5-HT3, allowing lipid S4-based LNPs to be targeted to the brain. Lipid S4 LNPs containing lipid S4 and encapsulating mRNA encoding GFP accumulate primarily in neurons, astrocytes, microglia, and brain capillary endothelial cells (BCECs) in mice. Lipid S4-containing LNPs encapsulating mRNA encoding a modified form of IL-12, which contains transcripts for IL-12 and a portion of the IL-12 receptor via a matrix metalloproteinase (MMP) linker, reduce tumor growth and increase survival in an orthotopic mouse model of glioblastoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cao, D., Hou, X., Wang, C., et al. Lipid nanoparticles for mRNA delivery in brain via systemic administration. Sci. Adv. 11(33), eadw0730 (2025).