A liver-activated prodrug form of adefovir
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Active Metabolite(s)
18650Adefovir
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Pradefovir (mesylate)

Item No. 45047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]ethyl]-9H-purin-6-amine, methanesulfonate
CAS Number
625095-61-6
Synonyms
  • MB06866
Molecular Formula
C17H19ClN5O4P • CH3SO3H
Formula Weight
519.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=[P@]1(O[C@H](C2=CC(Cl)=CC=C2)CCO1)COCCN3C4=NC=NC(N)=C4N=C3.CS(O)(=O)=O
InChi Code
InChI=1S/C17H19ClN5O4P.CH4O3S/c18-13-3-1-2-12(8-13)14-4-6-26-28(24,27-14)11-25-7-5-23-10-22-15-16(19)20-9-21-17(15)23;1-5(2,3)4/h1-3,8-10,14H,4-7,11H2,(H2,19,20,21);1H3,(H,2,3,4)/t14-,28+;/m0./s1
InChi Key
JXQUAHHUSMJUFV-HZPZRMRQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Pradefovir is a liver-activated prodrug form of the antiviral nucleoside analog adefovir (Item No. 18650).1 It is converted to adefovir diphosphate in the liver in rats when administered at a dose of 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reddy, K.R., Matelich, M.C., Ugarkar, B.G., et al. Pradefovir: A prodrug that targets adefovir to the liver for the treatment of hepatitis B. J. Med. Chem. 51(3), 666-676 (2008).