A DPP-4 inhibitor
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Retagliptin (phosphate)

Item No. 45052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-2 imidazo[1,5-a]pyrazine-1-carboxylic acid, methyl ester, monophosphate
CAS Number
1256756-88-3
Synonyms
  • SP2086
Molecular Formula
C19H18F6N4O3 • H3PO4
Formula Weight
562.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=P(O)(O)O.COC(C1=C2N(CCN(C2)C(C[C@H](N)CC3=C(C=C(C(F)=C3)F)F)=O)C(C(F)(F)F)=N1)=O
InChi Code
InChI=1S/C19H18F6N4O3.H3O4P/c1-32-17(31)16-14-8-28(2-3-29(14)18(27-16)19(23,24)25)15(30)6-10(26)4-9-5-12(21)13(22)7-11(9)20;1-5(2,3)4/h5,7,10H,2-4,6,8,26H2,1H3;(H3,1,2,3,4)/t10-;/m1./s1
InChi Key
SFNHOWDAQMIJPX-HNCPQSOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $94

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    25 mg

    $179

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    Product Description

    Retagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4).1 It induces autophagy and inhibits melanogenesis induced by α-melanocyte-stimulating hormone (α-MSH) in B16-F1 melanocytes when used at concentrations of 10 and 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, S.H., Bae, J.-E., Park, N., et al. Evaluation of teneligliptin and retagliptin on the clearance of melanosome by melanophagy in B16F1 cells. Cosmetics 11(2), 35 (2024).