A non-opioid analgesic
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Opiranserin (hydrochloride)

Item No. 45056

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-butoxy-N-[[4-(dimethylamino)tetrahydro-2H-pyran-4- yl]methyl]-3,5-dimethoxy-benzamide, monohydrochloride
CAS Number
1440796-75-7
Synonyms
  • VVZ-149
Molecular Formula
C21H34N2O5 • HCl
Formula Weight
431.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
COC1=CC(C(NCC2(N(C)C)CCOCC2)=O)=CC(OC)=C1OCCCC.Cl
InChi Code
InChI=1S/C21H34N2O5.ClH/c1-6-7-10-28-19-17(25-4)13-16(14-18(19)26-5)20(24)22-15-21(23(2)3)8-11-27-12-9-21;/h13-14H,6-12,15H2,1-5H3,(H,22,24);1H
InChi Key
GSCGQHXDHYVKOL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $59

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    5 mg

    $266

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    10 mg

    $443

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    25 mg

    $811

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    Product Description

    Opiranserin is a non-opioid analgesic.1 It is an inhibitor of glycine transporter 2 (GlyT2; IC50 = 0.86 µM) and an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A and the purinergic P2X3 receptor (IC50s = 1.3 and 0.87 µM, respectively). In vivo, opiranserin reduces mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 80 mg/kg). Formulations containing opiranserin have been used in the treatment of acute postoperative pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pang, M.-H., Kim, Y., Jung, K.W., et al. A series of case studies: Practical methodology for identifying antinociceptive multi-target drugs. Drug Discov. Today 17(9-10), 425-434 (2012).